The suppression of a mutation that has rendered a gene nonfunctional because the coding has changed to call for a wrong amino acid in the final polypeptide product, or even to call for a wrong stopping point. The mutation is suppressed when another mutation (a suppressor mutation) occurs which creates a mutant tRNA molecule that reads the mutated code as the normal code, and thus puts the correct amino acid into the final polypeptide product, thereby making the gene functional again. The original mutation is "fixed" as a result of another, independent mutation in a different gene. For an example of an intergenic suppression, see amber suppressor.
Selected intergenic suppression links:
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