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Whipple's disease

Whipple's disease is an illness affecting mainly men of middle age, with the clinical picture of nutritional malabsorption, diarrhea, joint pain and arthritis, and is caused by a Gram-positive bacillus: Tropheryma whippelii. Diagnosis is by endoscopic biopsy of the duodenum which demonstrates PAS-positive macrophages in the mucosa.

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