One of several factors used in calculating the reference dose from experimental data. UFs are intended to account for (1) the variation in sensitivity among humans; (2) the uncertainty in extrapolating animal data to humans; (3) the uncertainty in extrapolating data obtained in a study that covers less than the full life of the exposed animal or human; and (4) the uncertainty in using LOAEL data rather than NOAEL data.
Selected Uncertainty Factor links:
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